منابع مشابه
Circulating cell-free DNA content as blood based biomarker in endometrial cancer
Background Altered circulating cell-free DNA (cfDNA) levels are related to cancer development and aggressiveness. Up to now, very few studies have been performed for evaluating cfDNA content in endometrial cancer (EC). Methods First, we measured cfDNA release in blood serum of EC cancer patients collected before surgery and before the beginning of any treatment by SYBR Gold assay and correlat...
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Cardiovascular (CV) disease remains a major cause of mortality and morbidity worldwide, a widely spread illness worldwide and associated with increasing mortality within last decades [1]. Therefore, the high burden of CV and metabolic risk factors in different countries may have been affected the increased incidences of death in subjects prior to documentation of CV disease. In this context, it...
متن کاملFree circulating DNA as a biomarker of prostate cancer: comparison of quantitation methods.
AIM To identify a simpler method of free circulating DNA (fcDNA) quantitation that may improve the specificity of the prostate cancer prostate-specific antigen (PSA) screening test. MATERIALS AND METHODS The patient group consisted of 241 men with elevated PSA/abnormal digital rectal exam (DRE), undergoing prostate biopsy. Serum fcDNA levels were measured by UV absorbance and PicoGreen. Resul...
متن کاملCirculating Free DNA as Biomarker and Source for Mutation Detection in Metastatic Colorectal Cancer
BACKGROUND Circulating cell-free DNA (cfDNA) in plasma has shown potential as biomarker in various cancers and could become an importance source for tumour mutation detection. The objectives of our study were to establish a normal range of cfDNA in a cohort of healthy individuals and to compare this with four cohorts of metastatic colorectal cancer (mCRC) patients. We also investigated the prog...
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Circulating tumor DNA (ctDNA) in the blood of cancer patients contains much information on genetic and epigenetic profiles associated with cancer development, progression, and response to therapy. Analysis of ctDNA provides an opportunity for non-invasive sampling of tumor DNA repetitiously and therefore advance precision medicine. Recent development in massively parallel sequencing and digital...
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ژورنال
عنوان ژورنال: Nature Reviews Urology
سال: 2017
ISSN: 1759-4812,1759-4820
DOI: 10.1038/nrurol.2017.74